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Best Award Winner Advanced potency, easy cadence. Reap the rewards. Our highest concentration Regimen, ideal for skin that is preconditioned with Ramp-Up Regimen 2. Regimen 3 is comprised of the R3 Opoule™ Treatment 0. 1% Retinol and the RHR Overnight Mask What it is: Pure Retinol - the most effective form for cosmetic use to encourage rejuvenation, nestled within the Opoule Core and protected by the Coat for high stability &n